VIRALEZE SPL 7013: Antiviral Nasal Spray from Starpharma Australia 99.99% effective against Delta Variant
VIRALEZE™ has been developed by Starpharma, a world leader in the development of new medical products based on its proprietary dendrimer technology, as an antiviral nasal spray that is intended to provide a moisturising and protective barrier in the nose. VIRALEZE™ also contains astodrimer sodium (SPL7013), which has been shown in laboratory studies to inactivate a broad spectrum of respiratory/cold viruses.
The nasal cavity has been shown to be a primary site where respiratory viruses, including cold viruses and SARS-CoV-2 (the virus that causes COVID-19), become established, before spreading in the body (Hou et al, 2021).
Astodrimer sodium was originally developed by Starpharma for its antiviral activity and has been shown to block a broad-spectrum of viruses in nonclinical in vitro and in vivo studies (Bernstein et al, 2003; Jiang et al, 2005; Gong et al, 2005; Lackman-Smith et al, 2008; Tyssen et al, 2010; Telwatte et al, 2011; Romanowski et al, 2021).
Starpharma more recently announced the publication of laboratory data showing that astodrimer sodium also inactivates >99.9% of coronavirus SARS-CoV-2 (Paull et al, 2021).
Astodrimer has also been shown in laboratory studies conducted at the Scripps Research Institute to inactivate several SARS-CoV-2 “Variants of Concern”, including the Alpha, Beta, Gamma and Delta variants, with testing planned for other variants as they emerge and become available.
In addition, Starpharma announced that astodrimer sodium was shown in laboratory studies to block human respiratory syncytial virus (HRSV), and to block infection by other pandemic coronaviruses (SARS-CoV, MERS-CoV) and influenza viruses.
Astodrimer sodium is a patented, precisely designed large molecule that has been shown to not pass into the bloodstream following topical application to mucosal epithelial surfaces. In VIRALEZE™, astodrimer sodium is intended to form a barrier locally at site of application in the nasal cavity to trap and inactivate respiratory viruses.
Starpharma was awarded development funding for the development and commercialisation of VIRALEZE™ by the Australian Government’s Medical Research Future Fund Biomedical Translation Bridge Program.
VIRALEZE™ is registered for sale in Europe and India. VIRALEZE™ launched in the UK through LloydsPharmacy, as announced on 25 March 2021 and then in Europe via Starpharma’s www.viraleze.co webstore, as announced on 6 May 2021. Starpharma is also progressing regulatory activities for a number of markets, including Australia, with the intention of rolling it out across other markets. VIRALEZE™ is not approved for sale or supply in Australia.
Astodrimer sodium is also included in products approved in >45 countries and available for sale in the UK, Europe, Japan, South East Asia, Australia and New Zealand.
VIRALEZE™ mechanism of action
VIRALEZE™ is applied to the nasal cavity where respiratory viruses that cause colds, flu and more severe respiratory illness, first attach and start to multiply.
VIRALEZE™ provides a moisturising and protective barrier in the nose and contains astodrimer sodium (SPL7013), which physically traps and inactivates viruses. Astodrimer sodium has been shown in laboratory studies to inactivate viruses (Paull et al, 2021).
Astodrimer sodium (SPL7013) acts by trapping viruses, and blocking the interaction between virus attachment proteins, or “spikes”, and the human cells viruses are seeking to infect.
“Spike” proteins on the surface of viruses that come into contact with VIRALEZE™ are physically trapped by astodrimer sodium. This interaction is irreversible (“virucidal”) and blocked viruses can no longer infect cells.
The “blocked” viruses are then cleared naturally through the nasal mucus.
Hou, Y.J., et al. 2020. SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract. Cell 182(2), 429-446.e14.
Paull, J.R.A. et al. Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro (2021). Antiviral Research.
It was available to be purchased online in the UK until recently However sales were halted recently due to UK regulators questions over its covid claims sellers was https://Lloydspharmacy.com